Multiscale Modeling of Dyadic Structure-Function Relation in Ventricular Cardiac Myocytes.

ABSTRACT: Cardiovascular disease is often related to defects of subcellular components in cardiac myocytes, specifically in the dyadic cleft, which include changes in cleft geometry and channel placement. Modeling of these pathological changes requires both spatially resolved cleft as well as whole cell level descriptions. We use a multiscale model to create dyadic structure-function relationships to explore the impact of molecular changes on whole cell electrophysiology and calcium cycling. This multiscale model incorporates stochastic simulation of individual L-type calcium channels and ryanodine receptor channels, spatially detailed concentration dynamics in dyadic clefts, rabbit membrane potential dynamics, and a system of partial differential equations for myoplasmic and lumenal free Ca^2+<

SUBMITTER: Cosi FG 

PROVIDER: S-EPMC6990380 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature