Investigation of the Role of Myocyte Orientations in Cardiac Arrhythmia Using Image-Based Models.

ABSTRACT: Cardiac electrical excitation-propagation is influenced by myocyte orientations (cellular organization). Quantitatively understanding this relationship presents a significant research challenge, especially during arrhythmias in which excitation patterns become complex. Tissue-scale simulations of cardiac electrophysiology, incorporating both dynamic action potential behavior and image-based myocardial architecture, provide an approach to investigate three-dimensional (3D) propagation of excitation waves in the heart. In this study, we aimed to assess the importance of natural variation in myocyte orientations on cardiac arrhythmogenesis using 3D tissue electrophysiology simulations. Three anatomical models (i.e., describing myocyte orientations) of healthy rat ventricles-obtained using dif

SUBMITTER: Whittaker DG 

PROVIDER: S-EPMC6990390 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature