Selection on Aedes aegypti alters Wolbachia-mediated dengue virus blocking and fitness.

ABSTRACT: The dengue, Zika and chikungunya viruses are transmitted by the mosquito Aedes aegypti and pose a substantial threat to global public health. Current vaccines and mosquito control strategies have limited efficacy, so novel interventions are needed^1,2. Wolbachia are bacteria that inhabit insect cells and have been found to reduce viral infection-a phenotype that is referred to as viral 'blocking'³. Although not naturally found in A. aegypti⁴, Wolbachia were stably introduced into this mosquito in 2011^4,5 and were shown to reduce the transmission potential of dengue, Zika and chikungunya^6,7. Subsequent field trials showed Wolbachia's ability to spread through A. aegypti populations and reduce the local incidence of dengue fever⁸

SUBMITTER: Ford SA 

PROVIDER: S-EPMC6990461 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature