A mouse ear skin model to study the dynamics of innate immune responses against Staphylococcus aureus biofilms.

ABSTRACT: BACKGROUND:Staphylococcus aureus is a human pathogen that is a common cause of nosocomial infections and infections on indwelling medical devices, mainly due to its ability to shift between the planktonic and the biofilm/sessile lifestyle. Biofilm infections present a serious problem in human medicine as they often lead to bacterial persistence and thus to chronic infections. The immune responses elicited by biofilms have been described as specific and ineffective. In the few experiments performed in vivo, the importance of neutrophils and macrophages as a first line of defence against biofilm infections was clearly established. However, the bilateral interactions between biofilms and myeloid cells remain poorly studied and analysis of the dynamic processes at the cellular level in tissues

SUBMITTER: Abdul Hamid AI 

PROVIDER: S-EPMC6990489 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature