LiCoO₂ particles used in Li-ion batteries induce primary mutagenicity in lung cells via their capacity to generate hydroxyl radicals.

ABSTRACT:

Background

Li-ion batteries (LIB) are used in most portable electronics. Among a wide variety of materials, LiCoO₂ (LCO) is one of the most used for the cathode of LIB. LCO particles induce oxidative stress in mouse lungs due to their Co content, and have a strong inflammatory potential. In this study, we assessed the mutagenic potential of LCO particles in lung cells in comparison to another particulate material used in LIB, LTO (Li₄Ti₅O₁₂), which has a low inflammatory potential compared to LCO particles.

Results

We assessed the mutagenic potential of LCO and LTO particles in vitro by performing a cytokinesis-block micronucleus (MN) assay with rat lung epithelial cells (RLE), as well as in vivo in alveolar type II epithelial (AT-

SUBMITTER: Sironval V 

PROVIDER: S-EPMC6990559 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature