Comparison of various pharmaceutical properties of clobetasol propionate cream formulations - considering stability of mixture with moisturizer.

ABSTRACT:

Background

The clobetasol propionate cream formulations (CLB _Cr ) belong to the "strongest" group, and are used widely. In addition, those formulations are often used as a mixture with moisturizer. Recently, we evaluated pharmaceutical properties of the CLB _Cr using near infrared (NIR) spectroscopy, and characteristic NIR spectra depending on the formulation were observed. In the present study, we attempted to evaluate the more diverse pharmaceutical properties of CLB _Cr , including the stability of mixture of CLB _Cr and moisturizer.

Method

Pharmaceutical properties of CLB _Cr were evaluated using from rheological characteristics, microscopic observation, dye permeability observations, e

SUBMITTER: Yamamoto Y 

PROVIDER: S-EPMC6990562 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature