Simulation of Chordate Intron Evolution Using Randomly Generated and Mutated Base Sequences.

ABSTRACT: Introns are well known for their high variation not only in length but also in base sequence. The evolution of intron sequences has aroused broad interest in the past decades. However, very little is known about the evolutionary pattern of introns due to the lack of efficient analytical method. In this study, we designed 2 evolutionary models, that is, mutation-and-deletion (MD) and mutation-and-insertion (MI), to simulate intron evolution using randomly generated and mutated bases by referencing to the phylogenetic tree constructed using 14 chordate introns from TF4 (transcription factor-like protein 4) gene. A comparison of attributes between model-generated sequences and chordate introns showed that the MD model with proper parameter settings could generate sequences that have attribute

SUBMITTER: Wang GD 

PROVIDER: S-EPMC6990610 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature