Effect of Early Surgery vs Endoscopy-First Approach on Pain in Patients With Chronic Pancreatitis: The ESCAPE Randomized Clinical Trial.

ABSTRACT:

Importance

For patients with painful chronic pancreatitis, surgical treatment is postponed until medical and endoscopic treatment have failed. Observational studies have suggested that earlier surgery could mitigate disease progression, providing better pain control and preserving pancreatic function.

Objective

To determine whether early surgery is more effective than the endoscopy-first approach in terms of clinical outcomes.

Design, setting, and participants

The ESCAPE trial was an unblinded, multicenter, randomized clinical superiority trial involving 30 Dutch hospitals participating in the Dutch Pancreatitis Study Group. From April 2011 until September 2016, a total of 88 patients with chronic pancreatitis, a dilated main pancreatic duct, and who only recently sta

SUBMITTER: Issa Y 

PROVIDER: S-EPMC6990680 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature