Association of Apolipoprotein E ε4 With Medial Temporal Tau Independent of Amyloid-β.

ABSTRACT:

Importance

Apolipoprotein E ε4 (APOEε4) is the single most important genetic risk factor for Alzheimer disease. While APOEε4 is associated with increased amyloid-β burden, its association with cerebral tau pathology has been controversial.

Objective

To determine whether APOEε4 is associated with medial temporal tau pathology independently of amyloid-β, sex, clinical status, and age.

Design, setting, and participants

This is a study of 2 cross-sectional cohorts of volunteers who were cognitively normal, had mild cognitive impairment (MCI), or had Alzheimer disease dementia: the Translational Biomarkers in Aging and Dementia (TRIAD) study (data collected between October 2017 and July 2019) and the Alzheimer's Disease Neuroimaging Initiative (ADNI) (collected between Nov

SUBMITTER: Therriault J 

PROVIDER: S-EPMC6990684 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature