Associations Between Depression, Arterial Stiffness, and Metabolic Syndrome Among Adults in the UK Biobank Population Study: A Mediation Analysis.

ABSTRACT:

Importance

Previous research has linked a history of depression with arterial stiffness (AS) during midlife.

Objective

To assess the association of depression with elevated midlife AS and to investigate the extent to which this association is mediated via metabolic syndrome (MetS).

Design, settings, and participants

This population-based retrospective cohort study analyzed data collected between March 2006 and December 2010 from 124 445 participants aged 40 to 69 years from the UK Biobank. Participants without data on AS at baseline (n = 332 780) or who reported a previous diagnosis of cardiovascular disease (n = 45 374) were not eligible. Data analysis was performed from May to August 2019.

Exposures

Lifetime history of depression was assessed via verbal inter

SUBMITTER: Dregan A 

PROVIDER: S-EPMC6990710 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature