Rates of Discontinuation and Nonpublication of Head and Neck Cancer Randomized Clinical Trials.

ABSTRACT:

Importance

Randomized clinical trials (RCTs) play an important role in clinical decision-making, and discontinuation or nonpublication of these trials are causes of great concern. The extent of discontinued or unpublished RCTs about head and neck cancer remains unclear.

Objective

To assess the rate of discontinuation or nonpublication of RCTs involving patients with head and neck cancer. This objective was measured by observing 3 domains: discontinuation of trial, nonpublication of trial data, and feasibility of contacting trial investigators of aforementioned trials.

Evidence review

For this study, the sample was derived using the ClinicalTrials.gov advanced search feature on March 18, 2019, to locate completed and discontinued RCTs pertaining to head and neck cancer

SUBMITTER: Johnson AL 

PROVIDER: S-EPMC6990718 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature