Association of Maternal Psychological Distress With In Utero Brain Development in Fetuses With Congenital Heart Disease.

ABSTRACT:

Importance

Prenatal maternal psychological distress can result in detrimental mother and child outcomes. Maternal stress increases with receipt of a prenatal diagnosis of fetal congenital heart disease (CHD); however, the association between maternal stress and the developing brain in fetuses with CHD is unknown.

Objective

To determine the association of maternal psychological distress with brain development in fetuses with CHD.

Design, setting, and participants

This longitudinal, prospective, case-control study consecutively recruited 48 pregnant women carrying fetuses with CHD and 92 healthy volunteers with low-risk pregnancies from the Children's National Health System between January 2016 and September 2018. Data were analyzed between January 2016 and June 2019.

SUBMITTER: Wu Y 

PROVIDER: S-EPMC6990726 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature