Exosomes as mediators of neuron-glia communication in neuroinflammation.

ABSTRACT: In recent years, a type of extracellular vesicles named exosomes has emerged that play an important role in intercellular communication under physiological and pathological conditions. These nanovesicles (30-150 nm) contain proteins, RNAs and lipids, and their internalization by bystander cells could alter their normal functions. This review focuses on recent knowledge about exosomes as messengers of neuron-glia communication and their participation in the physiological and pathological functions in the central nervous system. Special emphasis is placed on the role of exosomes under toxic or pathological stimuli within the brain, in which the glial exosomes containing inflammatory molecules are able to communicate with neurons and contribute to the pathogenesis of neuroinflammation and neu

SUBMITTER: Pascual M 

PROVIDER: S-EPMC6990780 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature