Coronary Sinus Neuropeptide Y Levels and Adverse Outcomes in Patients With Stable Chronic Heart Failure.

ABSTRACT:

Importance

Chronic heart failure (CHF) is associated with increased sympathetic drive and may increase expression of the cotransmitter neuropeptide Y (NPY) within sympathetic neurons.

Objective

To determine whether myocardial NPY levels are associated with outcomes in patients with stable CHF.

Design, setting, and participants

Prospective observational cohort study conducted at a single-center, tertiary care hospital. Stable patients with heart failure undergoing elective cardiac resynchronization therapy device implantation between 2013 and 2015.

Main outcomes and measures

Chronic heart failure hospitalization, death, orthotopic heart transplantation, and ventricular assist device placement.

Results

Coronary sinus (CS) blood samples were obtained during

SUBMITTER: Ajijola OA 

PROVIDER: S-EPMC6990798 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature