Prognostic Value of Spreading Depolarizations in Patients With Severe Traumatic Brain Injury.

ABSTRACT:

Importance

Advances in treatment of traumatic brain injury are hindered by the inability to monitor pathological mechanisms in individual patients for targeted neuroprotective treatment. Spreading depolarizations, a mechanism of lesion development in animal models, are a novel candidate for clinical monitoring in patients with brain trauma who need surgery.

Objective

To test the null hypothesis that spreading depolarizations are not associated with worse neurologic outcomes.

Design, setting, and participants

This prospective, observational, multicenter cohort study was conducted from February 2009 to August 2013 in 5 level 1 trauma centers. Consecutive patients who required neurological surgery for treatment of acute brain trauma and for whom research consent could be

SUBMITTER: Hartings JA 

PROVIDER: S-EPMC6990808 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature