Safety and Efficacy of RimabotulinumtoxinB for Treatment of Sialorrhea in Adults: A Randomized Clinical Trial.

ABSTRACT:

Importance

RimabotulinumtoxinB (RIMA) may be preferable as an anti-sialorrhea treatment compared with current oral anticholinergic drugs in people with neurological disorders.

Objective

To assess the safety, efficacy, and tolerability of RIMA injections for the treatment of sialorrhea in adults.

Design, setting, and participants

This randomized, parallel, double-blind, placebo-controlled clinical trial of RIMA 2500 U and 3500 U was conducted from November 14, 2013, to January 23, 2017. A total of 249 adult patients with troublesome sialorrhea secondary to any disorder or cause were screened. Of them, 13 refused further participation in the study or were lost to follow-up and 49 did not fulfill the criteria for participation; 187 were ultimately enrolled. Patients had

SUBMITTER: Isaacson SH 

PROVIDER: S-EPMC6990829 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature