Association of Partial Chromosome 3 Deletion in Uveal Melanomas With Metastasis-Free Survival.

ABSTRACT:

Importance

Studies on uveal melanomas (UMs) have demonstrated the prognostic value of 8q gain and monosomy 3, but the prognosis of UMs with partial deletion of chromosome 3 remains to be defined.

Objective

To examine the association of partial chromosome 3 deletion in UMs with metastasis-free survival.

Design, setting, and participants

This retrospective cohort study of 1088 consecutive comparative genomic hybridization arrays performed from May 1, 2006, to July 31, 2015, assessed patients presenting with UMs with and without partial loss of chromosome 3 at a referral center. Data analysis was performed from September 1, 2017, to November 30, 2017.

Exposure

Uveal melanoma with or without partial loss of chromosome 3.

Main outcomes and measures

Metastasis

SUBMITTER: Rodrigues M 

PROVIDER: S-EPMC6990836 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature