Tau Positron Emission Tomographic Findings in a Former US Football Player With Pathologically Confirmed Chronic Traumatic Encephalopathy.

ABSTRACT:

Importance

Biomarkers for chronic traumatic encephalopathy (CTE) are currently lacking. The radiotracer fluorine F 18-labeled (18F)-flortaucipir (FTP) detects tau pathology in Alzheimer disease, and positron emission tomography (PET) with FTP shows elevated binding in individuals at risk for CTE. No study, however, has assessed the correlation between in vivo FTP PET and postmortem tau in CTE.

Objective

To assess the regional association between in vivo FTP binding and postmortem tau pathology in a patient with pathologically confirmed CTE.

Design, setting, and participants

A white male former National Football League player with 17 years of US football exposure was clinically diagnosed with traumatic encephalopathy syndrome at a neurology tertiary referral center. 18

SUBMITTER: Mantyh WG 

PROVIDER: S-EPMC6990867 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature