Efficacy and Safety of Lumateperone for Treatment of Schizophrenia: A Randomized Clinical Trial.

ABSTRACT:

Importance

Individuals living with schizophrenia are affected by cardiometabolic, endocrine, and motor adverse effects of current antipsychotic medications. Lumateperone is a serotonin, dopamine, and glutamate modulator with the potential to treat schizophrenia with few adverse effects.

Objective

To examine the efficacy and safety of lumateperone for the short-term treatment of schizophrenia.

Design, setting, and participants

This randomized, double-blind, placebo-controlled, phase 3 clinical trial was conducted from November 13, 2014, to July 20, 2015, with data analyses performed from August 13 to September 15, 2015. Patients with schizophrenia who were aged 18 to 60 years and were experiencing an acute exacerbation of psychosis were enrolled from 12 clinical sites

SUBMITTER: Correll CU 

PROVIDER: S-EPMC6990963 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature