The role of fuel type and combustion phase on the toxicity of biomass smoke following inhalation exposure in mice.

ABSTRACT: The characteristics of wildland fire smoke exposures which initiate or exacerbate cardiopulmonary conditions are unclear. We previously reported that, on a mass basis, lung toxicity associated with particulate matter (PM) from flaming smoke aspirated into mouse lungs is greater than smoldering PM. In this study, we developed a computer-controlled inhalation system which can precisely control complex biomass smoke emissions from different combustion conditions. This system was used to examine the toxicity of inhaled biomass smoke from peat, eucalyptus, and oak fuels generated under smoldering and flaming phases with emissions set to the same approximate concentration of carbon monoxide (CO) for each exposure (60-110 ppm), resulting in PM levels of ~ 4 mg/m³ for flaming and ~ 40 m

SUBMITTER: Kim YH 

PROVIDER: S-EPMC6991149 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature