Long-term Western diet intake leads to dysregulated bile acid signaling and dermatitis with Th2 and Th17 pathway features in mice.

ABSTRACT:

Background

Dietary interventions are implicated in the development of atopic dermatitis, psoriasis, and acne.

Objective

To investigate the effect of diet and the bile acid (BA) receptors, such as TGR5 (Takeda G protein receptor 5) and S1PR2 (sphingosine-1-phosphate receptor 2) in the development of dermatitis.

Methods

C57BL/6 mice were fed a control diet (CD) or Western diet (WD) since weaning until they were 10 months old followed by analyzing histology, gene expression, and BA profiling.

Results

Mice developed dermatitis as they aged and the incidence was higher in females than males. Additionally, WD intake substantially increased the incidence of dermatitis. Cutaneous antimicrobial peptide genesS100A8, S100A9, and Defb4 were reduced in WD-fed mice, but incr

SUBMITTER: Jena PK 

PROVIDER: S-EPMC6991164 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature