Comparison of Mortality and Major Cardiovascular Events Among Adults With Type 2 Diabetes Using Human vs Analogue Insulins.

ABSTRACT:

Importance

The comparative cardiovascular safety of analogue and human insulins in adults with type 2 diabetes who initiate insulin therapy in usual care settings has not been carefully evaluated using machine learning and other rigorous analytic methods.

Objective

To examine the association of analogue vs human insulin use with mortality and major cardiovascular events.

Design, setting, and participants

This retrospective cohort study included 127 600 adults aged 21 to 89 years with type 2 diabetes at 4 health care delivery systems who initiated insulin therapy from January 1, 2000, through December 31, 2013. Machine learning and rigorous inference methods with time-varying exposures were used to evaluate associations of continuous exposure to analogue vs human insul

SUBMITTER: Neugebauer R 

PROVIDER: S-EPMC6991251 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature