Prediagnostic Immune Cell Profiles and Breast Cancer.

ABSTRACT:

Importance

Higher overall leukocyte counts in women may be associated with increased risk of breast cancer, but the association of specific leukocyte subtypes with breast cancer risk remains unknown.

Objective

To determine associations between circulating leukocyte subtypes and risk of breast cancer.

Design, setting, and participants

Between 2003 and 2009, the Sister Study enrolled 50 884 women who had a sister previously diagnosed with breast cancer but were themselves breast cancer free. A case-cohort subsample was selected in July 2014 from the full Sister Study cohort. Blood samples were obtained at baseline, and women were followed up through October 2016. Data analysis was performed in April 2019.

Main outcomes and measures

The main outcome was the develo

SUBMITTER: Kresovich JK 

PROVIDER: S-EPMC6991268 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature