EphA2 contributes to disruption of the blood-brain barrier in cerebral malaria.
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ABSTRACT:
SUBMITTER: Darling TK
PROVIDER: S-EPMC6991964 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
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EphA2 contributes to disruption of the blood-brain barrier in cerebral malaria.
Darling Thayer K TK Mimche Patrice N PN Bray Christian C Umaru Banlanjo B Brady Lauren M LM Stone Colleen C Eboumbou Moukoko Carole Else CE Lane Thomas E TE Ayong Lawrence S LS Lamb Tracey J TJ
PLoS pathogens 20200130 1
Disruption of blood-brain barrier (BBB) function is a key feature of cerebral malaria. Increased barrier permeability occurs due to disassembly of tight and adherens junctions between endothelial cells, yet the mechanisms governing junction disassembly and vascular permeability during cerebral malaria remain poorly characterized. We found that EphA2 is a principal receptor tyrosine kinase mediating BBB breakdown during Plasmodium infection. Upregulated on brain microvascular endothelial cells in ...[more]
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