Associations between high blood pressure and DNA methylation.

ABSTRACT:

Background

High blood pressure is a major risk factor for cardiovascular disease and is influenced by both environmental and genetic factors. Epigenetic processes including DNA methylation potentially mediate the relationship between genetic factors, the environment and cardiovascular disease. Despite an increased risk of hypertension and cardiovascular disease in individuals of South Asians compared to Europeans, it is not clear whether associations between blood pressure and DNA methylation differ between these groups.

Methods

We performed an epigenome-wide association study and differentially methylated region (DMR) analysis to identify DNA methylation sites and regions that were associated with systolic blood pressure, diastolic blood pressure and hypertension. We analyz

SUBMITTER: Kazmi N 

PROVIDER: S-EPMC6991984 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature