Innervation of papillary thyroid cancer and its association with extra-thyroidal invasion.

ABSTRACT: Nerves are emerging regulators of cancer progression and in several malignancies innervation of the tumour microenvironment is associated with tumour aggressiveness. However, the innervation of thyroid cancer is unclear. Here, we investigated the presence of nerves in thyroid cancers and the potential associations with clinicopathological parameters. Nerves were detected by immunohistochemistry using the pan-neuronal marker PGP9.5 in whole-slide sections of papillary thyroid cancer (PTC) (n = 75), compared to follicular thyroid cancer (FTC) (n = 13), and benign thyroid tissues (n = 26). Nerves were detected in most normal thyroid tissues and thyroid cancers, but nerve density was increased in PTC (12 nerves/cm² [IQR 7-21]) compared to benign thyroid (6 nerves/cm² [IQR

SUBMITTER: Rowe CW 

PROVIDER: S-EPMC6992619 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature