Physical activity and risks of breast and colorectal cancer: a Mendelian randomisation analysis.

ABSTRACT: Physical activity has been associated with lower risks of breast and colorectal cancer in epidemiological studies; however, it is unknown if these associations are causal or confounded. In two-sample Mendelian randomisation analyses, using summary genetic data from the UK Biobank and GWA consortia, we found that a one standard deviation increment in average acceleration was associated with lower risks of breast cancer (odds ratio [OR]: 0.51, 95% confidence interval [CI]: 0.27 to 0.98, P-value = 0.04) and colorectal cancer (OR: 0.66, 95% CI: 0.48 to 0.90, P-value = 0.01). We found similar magnitude inverse associations for estrogen positive (ER^+ve) breast cancer and for colon cancer. Our results support a potentially causal relationship between higher physical activity levels and

SUBMITTER: Papadimitriou N 

PROVIDER: S-EPMC6992637 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature