Identification of AIDS-Associated Kaposi Sarcoma: A Functional Genomics Approach.

ABSTRACT:

Background

Kaposi sarcoma-associated herpes virus (KSHV) is one of the most common causal agents of Kaposi Sarcoma (KS) in individuals with HIV-infections. The virus has gained attention over the past few decades due to its remarkable pathogenic mechanisms. A group of genes, ORF71, ORF72, and ORF73, are expressed as polycistronic mRNAs and the functions of ORF71 and ORF72 in KSHV are already reported in the literature. However, the function of ORF73 has remained a mystery. The aim of this study is to conduct comprehensive exploratory experiments to clarify the role of ORF73 in KSHV pathology and discover markers of AIDS-associated KSHV-induced KS by bioinformatic approaches.

Methods and results

We searched for homologues of ORF-73 and attempted to predict protein-protein int

SUBMITTER: Zhang P 

PROVIDER: S-EPMC6992650 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature