An Ultrasonically Powered Implantable Microprobe for Electrolytic Ablation.

ABSTRACT: Electrolytic ablation (EA) is a promising nonthermal tumor ablation technique that destroys malignant cells through induction of a locoregional pH change. EA is typically performed by inserting needle electrodes inside the tumor followed by application of direct current (DC), thus inducing electrolysis and creating localized pH changes around the electrodes. In this paper, we report an ultrasonically powered implantable EA microprobe that may increase the clinical relevance of EA by allowing wireless control over device operation (capability to remotely turn the device on and off) and providing flexibility in treatment options (easier to administer fractionated doses over a longer period). The wireless EA microprobe consists of a millimeter-sized piezoelectric ultrasonic receiver, a rectif

SUBMITTER: Kim A 

PROVIDER: S-EPMC6992771 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature