Feasibility and clinical applications of multiple breath wash-out (MBW) testing using sulphur hexafluoride in adults with bronchial asthma.

ABSTRACT: Ventilation heterogeneity is frequent in bronchial asthma and can be assessed using multiple breath wash-out testing (MBW). Most data is available in paediatric patients and using nitrogen as a tracer gas. We aimed to evaluate sulphur hexafluoride (SF₆) MBW in adult asthmatics. Spirometry, whole-body plethysmography, impulse oscillometry and SF₆-MBW were prospectively performed. MBW parameters reflecting global (lung clearance index, LCI), acinar (S_acin) and conductive (S_cond) ventilation heterogeneity were derived from three consecutive wash-outs. LCI was calculated for the traditional 2.5% and an earlier 5% stopping point that has the potential to reduce wash-out times. 91 asthmatics (66%) and 47 non-asthmatic controls (34%) were included in fi

SUBMITTER: Trinkmann F 

PROVIDER: S-EPMC6992773 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature