The Exploration of Aroyltrimethylgermane as Potent Synthetic Origins and Their Preparation.

ABSTRACT: The synthetic utilities of acylgermanes are surprisingly rarely explored compared with their analogues. In this communication, the survey of aroyltrimethylgermane as potent synthetic origins has been studied. A variety of novel chemical transformations have been realized, including using the acylgermane group as a directing group in Rh-catalyzed aromatic C-H alkenylation reaction and Ir-catalyzed aromatic C-H amidation reactions. Additionally, a general approach for acylgermanes preparation has been established as well. The catalytic system proceeds effectively in the presence of Pd(OAc)₂/BINOL-based monophosphite (L11) and allows for the straightforward access to a wide range of functionalized acylgermanes in high yields.

SUBMITTER: Yuan Y 

PROVIDER: S-EPMC6992900 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature