Leukocyte telomere length is associated with aggressive prostate cancer in localized prostate cancer patients.

ABSTRACT:

Background

Telomeres play important roles in cancer initiation and progression. The aim of this study is to investigate whether leukocyte telomere length (LTL) is associated with aggressive prostate cancer (PCa).

Methods

We measured relative LTL in a cohort of 1,889 white PCa patients who were treated and followed up at the University of Texas MD Anderson Cancer Center and assessed its associations with aggressive disease characteristics at diagnosis and biochemical recurrence (BCR) after active treatments (radical prostatectomy and radiotherapy). We further used a Mendelian randomization (MR) approach to compute a weighted genetic risk score (GRS) predictive of LTL using 10 established LTL-associated genetic variants and determined whether this GRS is associated with aggres

SUBMITTER: Xu J 

PROVIDER: S-EPMC6992931 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature