Breast cancer induces systemic immune changes on cytokine signaling in peripheral blood monocytes and lymphocytes.

ABSTRACT:

Background

It is increasingly recognized that cancer progression induces systemic immune changes in the host. Alterations in number and function of immune cells have been identified in cancer patients' peripheral blood and lymphoid organs. Recently, we found dysregulated cytokine signaling in peripheral blood T cells from breast cancer (BC) patients, even those with localized disease.

Methods

We used phosphoflow cytometry to determine the clinical significance of cytokine signaling responsiveness in peripheral blood monocytes from non-metastatic BC patients at diagnosis. We also examined the correlation between cytokine signaling in peripheral monocytes and the number of tumor-infiltrating macrophages in paired breast tumors.

Findings

Our results show that cytokine (I

SUBMITTER: Wang L 

PROVIDER: S-EPMC6992943 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature