Gene expression dataset of prostate cells upon MIR205HG/LEADR modulation.

ABSTRACT: Although the role of miR-205 has been widely elucidated, the function of its host gene (MIR205HG) is yet to be clarified. We have recently investigated whether this gene is a simple endorsement for miRNA production or it may act independently, demonstrating its action as nuclear long noncoding RNA able to control basal-luminal differentiation in the human prostate context, thus deserving the reannotation as LEADR, Long Epithelial Alu-interacting Differentiation-related RNA. Here, we describe the loss and gain of function approaches experimentally used to modulate LEADR expression, and the bioinformatic procedures employed to analyze microarray data in our published article "LEADeR role of miR-205 host gene as long noncoding RNA in prostate basal cell diff

SUBMITTER: Percio S 

PROVIDER: S-EPMC6992947 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature