Depletion of SNAP-23 and Syntaxin 4 alters lipid droplet homeostasis during Chlamydia infection.

ABSTRACT: Chlamydia trachomatis is an obligate intracellular pathogen that replicates inside a parasitic vacuole called the inclusion. The nascent inclusion is derived from the host plasma membrane and serves as a platform from which Chlamydia controls interactions with the host microenvironment. To survive inside the host cell, Chlamydia scavenges for nutrients and lipids by recruiting and/or fusing with various cellular compartments. The mechanisms by which these events occur are poorly understood but require host proteins such as the SNARE proteins (SNAP (Soluble N-ethylmaleimide-sensitive factor attachment protein) Receptor). Here, we show that SNAP-23 and Syntaxin 4, two plasma membrane SNAREs, are recruited to the inclusion and play an important role in Chlamydia de

SUBMITTER: Monteiro-Bras T 

PROVIDER: S-EPMC6993123 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature