The "ART" of Epigenetics in Melanoma: From histone "Alterations, to Resistance and Therapies".

ABSTRACT: Malignant melanoma is the most deadly form of skin cancer. It originates from melanocytic cells and can also arise at other body sites. Early diagnosis and appropriate medical care offer excellent prognosis with up to 5-year survival rate in more than 95% of all patients. However, long-term survival rate for metastatic melanoma patients remains at only 5%. Indeed, malignant melanoma is known for its notorious resistance to most current therapies and is characterized by both genetic and epigenetic alterations. In cutaneous melanoma (CM), genetic alterations have been implicated in drug resistance, yet the main cause of this resistance seems to be non-genetic in nature with a change in transcription programs within cell subpopulations. This change can adapt and escape targeted therapy and im

SUBMITTER: Strub T 

PROVIDER: S-EPMC6993228 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature