Alveolar Stretch Activation of Endothelial Piezo1 Protects Adherens Junctions and Lung Vascular Barrier.

ABSTRACT: Disruption of alveolar-capillary barriers is a major complication of high-volume mechanical ventilation referred to as "ventilator-induced lung injury." The stretching force in alveoli is transmitted to endothelial cells, increasing the tension on underlying endothelial plasma membrane. The mechanosensor Piezo1, a plasma membrane cation channel, was inducibly deleted in endothelial cells of mice (Piezo1^iEC-/-), which allowed us to study its role in regulating the endothelial barrier response to alveolar stretch. We observed significant increase in lung vascular permeability in Piezo1^iEC-/- mice as compared with control Piezo1^fl/fl mice in response to high-volume mechanical ventilation. We also observed that huma

SUBMITTER: Zhong M 

PROVIDER: S-EPMC6993544 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature