LINC00844 promotes proliferation and migration of hepatocellular carcinoma by regulating NDRG1 expression.

ABSTRACT:

Background

Aberrant expression of long noncoding RNAs are implicated in the pathogenesis of human malignancies. LINC00844 expression is dramatically downregulated in prostate cancer, and functional studies have revealed the association between the aberrant expression of LINC00844 and prostate cancer cell invasion and metastasis. However, the function and mechanism of action of LINC00844 in the pathogenesis of hepatocellular carcinoma (HCC) are poorly understood.

Methods

LINC00844 and N-Myc downstream-regulated 1 (NDRG1) expression in HCC tissues and cell lines was detected with real-time quantitative polymerase chain reaction (RT-qPCR) and western blot analysis. Correlations between LINC00844 expression level and clinicopathological features were investigated using the origi

SUBMITTER: Zhou W 

PROVIDER: S-EPMC6993750 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature