Multiscale Characterization of Engineered Cardiac Tissue Architecture.

ABSTRACT: In a properly contracting cardiac muscle, many different subcellular structures are organized into an intricate architecture. While it has been observed that this organization is altered in pathological conditions, the relationship between length-scales and architecture has not been properly explored. In this work, we utilize a variety of architecture metrics to quantify organization and consistency of single structures over multiple scales, from subcellular to tissue scale as well as correlation of organization of multiple structures. Specifically, as the best way to characterize cardiac tissues, we chose the orientational and co-orientational order parameters (COOPs). Similarly, neonatal rat ventricular myocytes were selected for their consistent architectural behavior. The engineered ce

SUBMITTER: Drew NK 

PROVIDER: S-EPMC6993780 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature