Eutherian-Specific Gene TRIML2 Attenuates Inflammation in the Evolution of Placentation.

ABSTRACT: Evolution of highly invasive placentation in the stem lineage of eutherians and subsequent extension of pregnancy set eutherians apart from other mammals, that is, marsupials with short-lived placentas, and oviparous monotremes. Recent studies suggest that eutherian implantation evolved from marsupial attachment reaction, an inflammatory process induced by the direct contact of fetal placenta with maternal endometrium after the breakdown of the shell coat, and shortly before the onset of parturition. Unique to eutherians, a dramatic downregulation of inflammation after implantation prevents the onset of premature parturition, and is critical for the maintenance of gestation. This downregulation likely involved evolutionary changes on maternal as well as fetal/placental side. Tripartite-mot

SUBMITTER: Zhang X 

PROVIDER: S-EPMC6993854 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature