Putative human myometrial and fibroid stem-like cells have mesenchymal stem cell and endometrial stromal cell properties.

ABSTRACT:

Study question

Can endometrial stromal stem/progenitor cell markers, SUSD2 and CD146/CD140b, enrich for human myometrial and fibroid stem/progenitor cells?

Summary answer

SUSD2 enriches for myometrial and fibroid cells that have mesenchymal stem cell (MSC) characteristics and can also be induced to decidualise.

What is known already

Mesenchymal stem-like cells have been separately characterised in the endometrial stroma and myometrium and may contribute to diseases in their respective tissues.

Study design, size, duration

Normal myometrium, fibroids and endometrium were collected from hysterectomies with informed consent. Primary cells or tissues were used from at least three patient samples for each experiment.

Participants/materials, setting, methods

F

SUBMITTER: Patterson AL 

PROVIDER: S-EPMC6993861 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature