Human and Nonhuman Primate Lineage-Specific Footprints in the Salivary Proteome.

ABSTRACT: Proteins in saliva are needed for preprocessing food in the mouth, maintenance of tooth mineralization, and protection from microbial pathogens. Novel insights into human lineage-specific functions of salivary proteins and clues to their involvement in human disease can be gained through evolutionary studies, as recently shown for salivary amylase AMY1 and salivary agglutinin DMBT1/gp340. However, the entirety of proteins in saliva, the salivary proteome, has not yet been investigated from an evolutionary perspective. Here, we compared the proteomes of human saliva and the saliva of our closest extant evolutionary relatives, chimpanzees and gorillas, using macaques as an outgroup, with the aim to uncover features in saliva protein composition that are unique to each species. We found that

SUBMITTER: Thamadilok S 

PROVIDER: S-EPMC6993864 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature