A malaria parasite subtilisin propeptide-like protein is a potent inhibitor of the egress protease SUB1.

ABSTRACT: Subtilisin-like serine peptidases (subtilases) play important roles in the life cycle of many organisms, including the protozoan parasites that are the causative agent of malaria, Plasmodium spp. As with other peptidases, subtilase proteolytic activity has to be tightly regulated in order to prevent potentially deleterious uncontrolled protein degradation. Maturation of most subtilases requires the presence of an N-terminal propeptide that facilitates folding of the catalytic domain. Following its proteolytic cleavage, the propeptide acts as a transient, tightly bound inhibitor until its eventual complete removal to generate active protease. Here we report the identification of a stand-alone malaria parasite propeptide-like protein, called SUB1-ProM, encoded by a conserved gene that lies i

SUBMITTER: Tarr SJ 

PROVIDER: S-EPMC6993865 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature