Stimulus-Responsive Anti-Oxidizing Drug Crystals and their Ecological Implication.

ABSTRACT: Various antioxidants are being used to neutralize the harmful effects of reactive oxygen species (ROS) overproduced in diseased tissues and contaminated environments. Polymer-directed crystallization of antioxidants has attracted attention as a way to control drug efficacy through molecular dissolution. However, most recrystallized antioxidants undertake continuous dissolution independent of the ROS level, thus causing side-effects. This study demonstrates a unique method to assemble antioxidant crystals that modulate their dissolution rate in response to the ROS level. We hypothesized that antioxidants recrystallized using a ROS-labile polymer would be triggered to dissolve when the ROS level increases. We examined this hypothesis by using catechin as a model antioxidant. Catechin was rec

SUBMITTER: Kim BS 

PROVIDER: S-EPMC6993893 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature