Chimeric antigen receptor T-cell approaches to HIV cure.

ABSTRACT:

Purpose of review

Combination antiretroviral therapy (ART) has enabled tremendous progress in suppressing HIV replication in infected patients. However, ART alone cannot eradicate HIV and its latent, persisting reservoirs. Novel approaches are needed to eradicate the virus or achieve functional cure in the absence of ART.

Recent findings

Adoptive T-cell therapies were initially tested in HIV-infected individuals with limited efficiency. Benefiting from new and improved methodologies, an increasing array of CAR T-cell therapies has been successfully developed in the cancer immunotherapy field, demonstrating promising new avenues that could be applied to HIV. Numerous studies have characterized various HIV-specific CAR constructs, types of cytolytic effector cells, and CAR-exp

SUBMITTER: Kuhlmann AS 

PROVIDER: S-EPMC6993924 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature