The impact of early adjuvant chemotherapy in rectal cancer.

ABSTRACT:

Purposes

Although adjuvant chemotherapy (AC) has been established as a standard of treatment for advanced rectal cancer, there is no guideline regarding the timing of AC initiation. In this study, we aimed to evaluate the oncologic outcome of early AC initiation and clarify the ideal time to AC among rectal cancer patients receiving preoperative chemo-radiotherapy (preCRT).

Methods

The medical records of 719 patients who underwent curative resection followed by AC for rectal cancer were analyzed retrospectively. Data distributions were compared according to the calculated cut-off for AC initiation, survival results, and chemotherapy-induced toxicity. Additionally, patients were divided into two groups according to preCRT status and compared with respect to differences in the

SUBMITTER: Noh GT 

PROVIDER: S-EPMC6993968 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature