Methotrexate for the Treatment of Pediatric Crohn's Disease: A Systematic Review and Meta-analysis.

ABSTRACT:

Background

Methotrexate (MTX) is an immunomodulator used for the treatment of pediatric inflammatory bowel disease (IBD). There are currently no RCTs that assess the treatment efficacy of methotrexate within the pediatric IBD patient population. This systematic review and meta-analysis assesses the efficacy of MTX therapy among the existing pediatric literature.

Methods

A systematic literature search was performed using MEDLINE and the Cochrane library from inception until March 2016. Synonyms for 'pediatric', 'methotrexate' and 'IBD' were utilized as both free text and MESH search terms. The studies included contained clinical remission (CR) rates for MTX treatment of pediatric IBD patients 18 yrs old, as mono- or combination therapy. Case studies with <10 patients were exc

SUBMITTER: Colman RJ 

PROVIDER: S-EPMC6994018 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature