Selective induction of antibody effector functional responses using MF59-adjuvanted vaccination.

ABSTRACT: Seasonal and pandemic influenza infection remains a major public health concern worldwide. Driving robust humoral immunity has been a challenge given preexisting, often cross-reactive, immunity and in particular, poorly immunogenic avian antigens. To overcome immune barriers, the adjuvant MF59 has been used in seasonal influenza vaccines to increase antibody titers and improve neutralizing activity, translating to a moderate increase in protection in vulnerable populations. However, its effects on stimulating antibody effector functions, including NK cell activation, monocyte phagocytosis, and complement activity, all of which have been implicated in protection against influenza, have yet to be defined. Using systems serology, we assessed changes in antibody functional profiles in individu

SUBMITTER: Boudreau CM 

PROVIDER: S-EPMC6994146 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature