The conserved transcriptional regulator CdnL is required for metabolic homeostasis and morphogenesis in Caulobacter.

ABSTRACT: Bacterial growth and division require regulated synthesis of the macromolecules used to expand and replicate components of the cell. Transcription of housekeeping genes required for metabolic homeostasis and cell proliferation is guided by the sigma factor σ70. The conserved CarD-like transcriptional regulator, CdnL, associates with promoter regions where σ70 localizes and stabilizes the open promoter complex. However, the contributions of CdnL to metabolic homeostasis and bacterial physiology are not well understood. Here, we show that Caulobacter crescentus cells lacking CdnL have severe morphological and growth defects. Specifically, ΔcdnL cells grow slowly in both rich and defined media, and are wider, more curved, and have shorter stalks than WT cells. These defects arise from transcr

SUBMITTER: Woldemeskel SA 

PROVIDER: S-EPMC6994171 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature