A role for triglyceride lipase brummer in the regulation of sex differences in Drosophila fat storage and breakdown.

ABSTRACT: Triglycerides are the major form of stored fat in all animals. One important determinant of whole-body fat storage is whether an animal is male or female. Here, we use Drosophila, an established model for studies on triglyceride metabolism, to gain insight into the genes and physiological mechanisms that contribute to sex differences in fat storage. Our analysis of triglyceride storage and breakdown in both sexes identified a role for triglyceride lipase brummer (bmm) in the regulation of sex differences in triglyceride homeostasis. Normally, male flies have higher levels of bmm mRNA both under normal culture conditions and in response to starvation, a lipolytic stimulus. We find that loss of bmm largely eliminates the sex difference in triglyceride storage and abolishes the sex difference

SUBMITTER: Wat LW 

PROVIDER: S-EPMC6994176 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature